Pharmanza Herbal

Research Publications

  • Hingorani L, Ebersole B, inventors; Verdure Sciences, assignee. Stable solid lipid particle composition for improved bioavailability of lipophilic compounds for age-related diseases. United States patent US 10,588,866. 2020 Mar 17.
  • Hingorani L, Ebersole B, Patel S. Optimization and validation of ursolic acid by HPLC in Ocimum sanctum. Planta Medica. 2012 Jul;78(11):PJ17.
  • Hingorani L, Mehta D, Vaidya R, Vaidya AB. Relevance of Fast Track Integrative Approaches for the Control of COVID-19. The Indian Practitioner. 2020 Jun 16;73(5):44-7.
  • Hingorani L, Patel S, Darji B, Ebersole B. Orthogonal validation of analytical and quality systems for botanical products. Planta Medica. 2012 Jul;78(11):PJ156. 
  • Hingorani L, Patel S, Ebersole B. Sustained cognitive effects and safety of HPLC-standardized Bacopa monnieri extract: a randomized, placebo controlled clinical trial. Planta Medica. 2012 Jul;78(11):PH22.
  • Hingorani L, Seeram NP, Ebersole B. High-throughput screening program for botanical extracts. Planta Medica. 2012 Jul;78(11):PF85.
  • Hingorani L. 5 Bacognize. Natural Medicines: Clinical Efficacy, Safety and Quality. 2019 Jul 18:87.
  • Hingorani L. Bacognize: A Standardised Extract of Bacopa monnieri. InNatural Medicines 2019 Jul 18 (pp. 87-107). CRC Press.
  • Acharya N, Acharya S, Shah U, Shah R, Hingorani L. A comprehensive analysis on Symplocos racemosa Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities. Journal of ethnopharmacology. 2016 Apr 2;181:236-51. 
  • Acharya NS, Shah UR, Shah RG, Acharya S, Hingorani L. Evaluation of in vitro anticancer activity of Symplocos racemosa bark against hepatocellular carcinoma. International Journal of Pharmacy and Pharmaceutical Sciences. 2015 Nov 1:384-5. 
  • Thawani V, Hingorani L. Effect of herbal combination of triphala and Garcinia cambogia extracts on liver function test and kidney function test in high fat diet induced obesity in rats. 
  • Azazahemad A. Kureshi, Sautik Ghoshal, Suraj Adsare, Ganesh Saste, Amit Mirgal, Aboli Girme, and Lal Hingorani “Distinct Morphological and Analytical Features of Spinacia oleracea Differentiating from Conventional Spinach Plants” ACS Food Science & Technology 2023 3 (2), 273-282 DOI: 10.1021/acsfoodscitech.2c00300
  • Badar VA, Thawani VR, Wakode PT, Shrivastava MP, Gharpure KJ, Hingorani LL, Khiyani RM. Efficacy of Tinospora cordifolia in allergic rhinitis. Journal of ethnopharmacology. 2005 Jan 15;96(3):445-9.
  • Borse S, Joshi M, Saggam A, Bhat V, Walia S, Marathe A, Sagar S, Chavan-Gautam P, Girme A, Hingorani L, Tillu G. Ayurveda botanicals in COVID-19 management: An in silico multi-target approach. Plos one. 2021 Jun 11;16(6):e0248479.
  • Chaturvedi PA, Hingorani L. Media standardization for enhanced production of bacoside of Bacopa monnieri In situ condition. Pharmacognosy Magazine. 2018 Jun 1;14(55):32. 
  • D Nagda C, P Chotai N, C Nagda D, B Patel S, L Patel U. Preparation and characterization of spray-dried mucoadhesive microspheres of ketorolac for nasal administration. Current drug delivery. 2012 Mar 1;9(2):205-18.
  • Gaikar N, Raval M, Patel S, Patel P, Hingorani L. Isolation, characterization and estimation of benzoxazinoid glycoside from seeds of Blepharis persica (Burm. f) O. Kuntze. Separation Science Plus. 2021 Apr;4(4):163-73.
  • Gaikar NV, Raval MA, Patel SG, Hingorani LL. Isolation and characterization of flavonoids from fraction of Blepharis persica (Burm. f.) O. Kuntze upregulated testosterone biosynthesis in vitro using TM3 leydig cells. Pharmacognosy Magazine. 2021 Jan 1;17(5):29.
  • Ganesh Saste, Arun Kumar Balasubramaniam, Ruchi Singh, Saurabh Patel, Shubham Jagtap, Samir Patel, Rakesh Maurya, Girme A.S., Lal Hingorani “Comprehensive standardization and rapid quality evaluation of isoflavones and isoflavone glycosides from Dalbergia sissoo by ultra-high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry” Sep Sci plus. DOI: https://doi.org/10.1002/sscp.202200079
  • Girme A, Bhoj P, Saste G, Pawar S, Mirgal A, Raut D, Chavan M, Hingorani L. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus. Journal of AOAC International. 2021 Apr 30.
  • Girme Aboli, Vijay Parmar , Shubham Jagtap , Ganesh Saste , Siddharth J. Modi, Lal Hingorani “Development and validation of UHPLC-ESI-MS/MS bioanalytical method, ADMET profiling, and pharmacokinetic study of bioactive phytoconstituents from Ayurvedic botanical Guduchi (Tinospora cordifolia)” Journal of Pharmaceutical and Biomedical Analysis Open 2 (2023) 100018 https://doi.org/10.1016/j.jpbao.2023.100018
  • Girme A, Ghule C, Gaikar N, Hingorani L. Rapid and sensitive High-Performance Thin-Layer Chromatographic (HPTLC) method for identification and quantification of luteolin by densitometry in Kasamarda (Cassia occidentalis L.). Indian Journal of Traditional Knowledge (IJTK). 2021 Aug 18;20(3):700-6.
  • Girme A, Saste G, Balasubramaniam AK, Ghule C, Mulay V, Hingorani L. Development, and validation of novel quality evaluation methods to differentiate two closely related species of Tinospora: A rapid HPTLC and HPLC-based assessment with -MS/MS characterization. J AOAC Int. 2023 Sep 20:qsad110. doi: 10.1093/jaoacint/qsad110. Epub ahead of print. PMID: 37738282.
  • Girme A, Saste G, Balasubramaniam AK, Pawar S, Ghule C, Hingorani L. Assessment of Curcuma longa extract for adulteration with synthetic curcumin by analytical investigations. Journal of Pharmaceutical and Biomedical Analysis. 2020 Nov 30;191:113603.
  • Girme A, Saste G, Chinchansure A, Joshi S, Kunkulol R, Hingorani L, Patwardhan B. Simultaneous Determination of Anthraquinone, Flavonoids, and Phenolic Antidiabetic Compounds from Cassia auriculata Seeds by Validated UHPLC Based MS/MS Method. Mass Spectrometry Letters. 2020;11(4):82-9.
  • Girme A, Saste G, Pawar S, Balasubramaniam AK, Musande K, Darji B, Satti NK, Verma MK, Anand R, Singh R, Vishwakarma RA. Investigating 11 Withanosides and Withanolides by UHPLC–PDA and Mass Fragmentation Studies from Ashwagandha (Withania somnifera). ACS omega. 2020 Oct 21;5(43):27933-43.
  • Girme A, Saste G, Pawar S, Ghule C, Mirgal A, Patel N, Singh R, Hingorani L. A sensitive analysis of ellagic acid dietary supplements by UFLC-PDA-MS/MS from Punica granatum: An application for botanical sourcing and adulteration. Current Topics in Nutraceutical Research, 2021. 19(1): 90
  • Girme A, Saste G, Pawar S, Ghule C, Mirgal A, Patel N, Singh R, Hingorani L. Development and Validation of a Sensitive Method for Analysis of Ellagic Acid in Dietary Supplements from Punica granatum. Current Topics in Nutraceutical Research. 2021 Feb 1;19(1).
  • Girme A, Saste G, Pawar S, Ghule C, Mirgal A, Patel S, Tiwari A, Ghoshal S, Bharate SB, Bharate SS, Reddy DS. Quantitative Determination and Characterization of a Kashmir Saffron (Crocus sativus L.)-Based Botanical Supplement Using Single-Laboratory Validation Study by HPLC-PDA with LC–MS/MS and HPTLC Investigations. ACS omega. 2021 Aug 30;6(36):23460-74.
  • Girme A, Saste G, Pawar S, Singh R, Hingorani L. Investigation of ellagic acid sourcing as a dietary supplement by UFLC-PDA-ESI-MS/MS. Planta Medica. 2019 Dec;85(18):P-485.
  • Girme A, Saste G, Pawar S, Singh R, Hingorani L. Investigation of ellagic acid sourcing as a dietary supplement by UFLC-PDA-ESI-MS/MS. Planta Medica. 2019 Dec;85(18):P-485.
  • Girme A.S., Ganesh Saste, Ruchi Singh, et al. “”Quantitative and rapid quality assessment methods for the multi-class bioactive constituents of Tinospora cordifolia using high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization”. Sep Sci plus. 2022; 5: 378– 392.  DOI:https://doi.org/10.1002/sscp.202200048
  • Girme A.S., Mirgal A, Darji B, Gafner S, Hingorani L. Adulteration of saffron and saffron extracts. Botanical Adulterants Prevention Bulletin. Austin, TX: USA. ABC-AHP-NCNPR Botanical Adulterants Prevention Program; 2022.
  • Girme A.S., Pawar, S.; Ghule, C.; Shengule, S.; Saste, G.; Balasubramaniam, A.K.; Deshmukh, A.; Hingorani, L. Bioanalytical Method Development and Validation Study of Neuroprotective Extract of Kashmiri Saffron Using Ultra-Fast Liquid Chromatography-Tandem Mass Spectrometry (UFLC-MS/MS): In Vivo Pharmacokinetics of Apocarotenoids and Carotenoids. Molecules 2021, 26, 1815. DOI:10.3390/molecules26061815
  • Girme AS, Saste GB, Shengule SA, Kunkulol RR, Hingorani LL. Method development, optimization and validation of RP-UFLC method for bioactive flavonoids from Cassia auriculata. J Pharmacog Phytochem. 2019;8(1):77-81. 
  • Girme, Aboli, Ganesh Saste, Arun Kumar Balasubramaniam, Chetana Ghule, Vallabh Mulay, and Lal Hingorani. “Development and Validation of Novel Quality Evaluation Methods to Differentiate Two Closely Related Species of Tinospora: A Rapid HPTLC-and HPLC-Based Assessment with MS/MS Characterization.” Journal of AOAC International (2023): qsad110.  https://doi.org/10.1093/jaoacint/qsad110 
  • Gohel K, Patel K, Shah P, Hingorani L, Gandhi T. Box–Behnken design-assisted optimization for simultaneous estimation of quercetin, kaempferol, and keto-β-boswellic acid by high-performance thin-layer chromatography method. JPC-Journal of Planar Chromatography-Modern TLC. 2018 Aug;31(4):318-26. 
  • Gohel M, Kureshi R, Hingorani L, Patel A, Thakkar V, Baldaniya L, Gandhi T. Article Details Formulation and evaluation of Self-nano emulsifying Drug Delivery System For solubility and bioavailability Enhancement of poorly water soluble Withaferin A. 
  • Gohel MU, Patel A, Patel AS, Hingorani L. Optimization of Bacoside, a loaded SNEDDS, using D-optimal mixture design for enhancement in solubility and bio-availability. Int J Pharm Pharm Sci. 2016 Dec;8(12):213-20. 
  • Gota P, Adegoke A, Gurjar M, Singh S, Nandave M, Hingorani L, Gota V. Comparison of the metabolic stability of solid lipid boswellia serrata particles versus plain boswellia serrata extract in human hepatocytes (hhl-17). International Journal of Pharmaceutical, Chemical & Biological Sciences. 2016 Jan 1;6(1). 
  • Gupte PA, Giramkar SA, Harke SM, Kulkarni SK, Deshmukh AP, Hingorani LL, Mahajan MP, Bhalerao SS. Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: A pilot clinical study. Journal of inflammation research. 2019;12:145.
  • Ishita A. Basera, Girme A.S, Vijay P. Bhatt, Ganesh Saste, Sandeep Pawar, Lal Hingorani, Mamta B. Shah., “Development of Validated UHPLC–PDA with ESI–MS-MS Method for Concurrent Estimation of Magnoflorine, Berbamine, Columbamine, Jatrorrhizine, Palmatine and Berberine in Berberis aristata” Acta Chromatographica 34.4 (2022): 412-421.DOI:10.1556/1326.2021.00960
  • Jadhav P, Kapoor N, Thomas B, Lal H, Kshirsagar N. Antiviral potential of selected Indian medicinal (ayurvedic) plants against herpes simplex virus 1 and 2. North American journal of medical sciences. 2012 Dec;4(12):641.
  • Jadhav P, Lal H, Kshirsagar N. Assessment of potency of PC-complexed Ocimum sanctum methanol extract in embryonated eggs against Influenza virus (H1N1). Pharmacognosy magazine. 2014 Jan;10(Suppl 1):S86.
  • Joshi JV, Jagtap S, Walwatkar P, Rastogi N, Nabar N, Agashe S, Hingorani L, Vaidya A. Integrated Non-invasive Management of Cervical Low-Grade Squamous Intraepithelial Lesions Observed in Papanicolaou Smears with Antimicrobials Followed by Oral Curcuma Longa Extract. Asian Pacific Journal of Cancer Biology. 2020 Sep 15;5(3):89-97.
  • Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double-blind placebo controlled trial. Phytomedicine. 2003 Jan 1;10(1):3-7.
  • Kothari P, Sinha S, Sardar A, Tripathi AK, Girme A, Adhikary S, Singh R, Maurya R, Mishra PR, Hingorani L, Trivedi R. Inhibition of cartilage degeneration and subchondral bone deterioration by Spinacia oleracea in human mimic of ACLT-induced osteoarthritis. Food & Function. 2020;11(9):8273-85.
  • Kothari P, Sinha S, Sardar A, Tripathi AK, Girme A, Adhikary S, Singh R, Maurya R, Mishra PR, Hingorani L, Trivedi R. Inhibition of cartilage degeneration and subchondral bone deterioration by Spinacia oleracea in human mimic of ACLT-induced osteoarthritis. Food & Function. 2020;11(9):8273-85. 
  • Kothari P, Tripathi AK, Girme A, Rai D, Singh R, Sinha S, Choudhary D, Nagar GK, Maurya R, Hingorani L, Trivedi R. Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins. Journal of ethnopharmacology. 2022 Jan 10;282:114315.
  • Kulkarni PD, Damle ND, Hingorani L, Bhaskar VH, Ghante MR, Patil A, Gurjar M, Gota V. Pharmacokinetics of solid lipid Boswellia serrata particles in healthy subjects. Drug Metabolism and Personalized Therapy. 2021 Apr 5.
  • Kulkarni PD, Damle ND, Singh S, Yadav KS, Ghante MR, Bhaskar VH, Hingorani L, Gota VS. Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee. Drug metabolism and personalized therapy. 2020 Jun 1;35(2).
  • Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L, Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. Journal of agricultural and food chemistry. 2006 Nov 15;54(23):8956-61. 
  • Mistry NN, Shah P, Patel K, Hingorani L. Simultaneous estimation of stigmasterol and Withaferin A in union total herbal formulation using validated HPTLC method. Journal of Applied Pharmaceutical Science. 2015 Aug;5(08):159-66. 
  • Modi SJ, Tiwari A, Ghule C, Pawar S, Saste G, Jagtap S, Singh R, Deshmukh A, Girme A.S., Hingorani L. Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS). Molecules. 2022 Feb 22;27(5):1476. doi: 10.3390/molecules27051476. 
  • Niyati A, Unnati S, Lal H, Sanjeev A. Anti-oxidant and anti-cancer potential of Symplocos racemosa bark against Hep3B cell line. International Journal of Pharmaceutical Sciences and Research (IJPSR). 2015;6(10):4529-33.
  • Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. Journal of agricultural and food chemistry. 2008 Sep 24;56(18):8434-41.
  • Panda V, Deshmukh A, Hare A, Singh S, Hingorani L, Sudhamani S. Effect of Withania somnifera hydroalcoholic extract and other dietary interventions in improving muscle strength in aging rats. Journal of Ayurveda and Integrative Medicine. 2021 Nov 9.
  • Panda V, Deshmukh A, Singh S, Shah T, Hingorani L. An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: Involvement of curcuminoids and polyphenolics. Journal of Ayurveda and Integrative Medicine. 2021 Jul 1;12(3):506-13.
  • Patel C, Dadhaniya P, Hingorani L, Soni MG. Safety assessment of pomegranate fruit extract: acute and subchronic toxicity studies. Food and Chemical Toxicology. 2008 Aug 1;46(8):2728-35.
  • Patel K, Patel HJ, Christian J, Hingorani L, Gandhi T. Analytical QbD: Designing Space for HPLC Method Operable Region for Estimation of Preservatives in Herbal Formulation. Current Pharmaceutical Analysis. 2019 Apr 1;15(2):152-64.
  • Patel R, Tripathi C, Girme A, Champaneri S, Patel RJ, Hingorani L. Nutraceutical regulations: An opportunity in ASEAN countries.
  • Patel SB, Rao NJ, Hingorani LL. Safety assessment of Withania somnifera extract standardized for Withaferin A: Acute and sub-acute toxicity study. Journal of Ayurveda and integrative medicine. 2016 Mar 1;7(1):30-7. 
  • Patel U, Girme A, Patel K, Ghule C, Hingorani L, Gandhi T. A validated HPTLC method for quantification of cordifolioside A, 20-β-hydroxyecdysone and columbin with HPTLC–ESI–MS/MS characterization in stems of Tinospora cordifolia. JPC–Journal of Planar Chromatography–Modern TLC. 2021 Jun;34(3):217-28.
  • Priyanka J, Hingorani L, Nilima K. Pharmacodynamic evaluation for antiplasmodial activity of Holarrhena antidysentrica (Kutaja) and Azadirachta indica (Neemb) in Plasmodium berghei infected mice model. Asian Pacific journal of tropical medicine. 2013 Jul 1;6(7):520-4.
  • Sarang D. Thawani Vijay Gharpure Kunda Apte Indrayani Masand Anil Hingorani Lal and Khiyani Raj. Effect of Herbal Combination in Low Bone Mass Density Patients. International Journal of Drug Discovery and Technology. 2011;2(1):9-14.
  • Sautik Ghoshal, Chetana Ghule, Amit Mirgal, Girme A.S., and Lal Hingorani “Ghoshal, S., Ghule, C., Mirgal, A. et al. Recent findings by high-performance thin-layer chromatographic separation for a comprehensive analysis of Withania somnifera by densitometry and mass spectrometry: an assessment to quality and adulteration. JPC-J Planar Chromat (2022). DOI:10.1007/s00764-022-00187-z 
  • Shah J, Patel S, Ebersole B, Hingorani L. Acute human pharmacokinetics of a lipid-dissolved turmeric extract. Planta Medica. 2012 Jul;78(11):PH5.
  • Shah UM, Patel SM, Patel PH, Hingorani L, Jadhav RB. Development and validation of a simple isocratic HPLC method for simultaneous estimation of phytosterols in Cissus quadrangularis. Indian journal of pharmaceutical sciences. 2010 Nov;72(6):753.
  • Shah UM, Patel SM, Patel PH, Hingorani L, Jadhav RB. Development and validation of a simple isocratic HPLC method for simultaneous estimation of phytosterols in Cissus quadrangularis. Indian journal of pharmaceutical sciences. 2010 Nov;72(6):753.
  • Sharma S, Thawani V, Hingorani L, Shrivastava M, Bhate VR, Khiyani R. Pharmacokinetic study of 11-keto β-Boswellic acid. Phytomedicine. 2004 Jan 1;11(2-3):255-60.
  • Shinde S, Balasubramaniam AK, Mulay V, Saste G, Girme A, Hingorani L. Recent Advancements in Extraction Techniques of Ashwagandha (Withania somnifera) with Insights on Phytochemicals, Structural Significance, Pharmacology, and Current Trends in Food Applications. ACS Omega. 2023 Oct 27;8(44):40982-41003. doi: 10.1021/acsomega.3c03491. PMID: 37970011; PMCID: PMC10633886.
  • Shinde, Sunil, Arun Kumar Balasubramaniam, Vallabh Mulay, Ganesh Saste, Aboli Girme, and Lal Hingorani. “Recent Advancements in Extraction Techniques of Ashwagandha (Withania somnifera) with Insights on Phytochemicals, Structural Significance, Pharmacology, and Current Trends in Food Applications.” ACS omega (2023). https://doi.org/10.1021/acsomega.3c03491 
  • Soni T, Chotai N, Patel P, Hingorani L, Shah R, Patel N, Gandhi T. Evaluation of an optimum regression model for high-performance thin-layer chromatographic analysis of aceclofenac in plasma. JPC-Journal of Planar Chromatography-Modern TLC. 2009 Apr 1;22(2):101-7.
  • Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian Journal of Pharmacology. 2007 Jan 1;39(1):27.
  • Thakkar VT, Deshmukh A, Hingorani L, Juneja P, Baldaniya L, Patel A, Pandya T, Gohel M. Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement. Journal of pharmacy & bioallied sciences. 2017 Jul;9(3):208. 
  • Thakur A, Jain V, Hingorani L, Laddha KS. Phytochemical studies on Cissus quadrangularis Linn. Pharmacognosy Research. 2009;1(4).
  • Thakur AK, Jain V, Hingorani L, Laddha KS. Improved high-performance liquid chromatography-DAD method for the simultaneous analysis of quercetin and kaempferol in the stems of Cissus quadrangularis Linn. Acta Chromatographica. 2009 Mar 1;21(1):95-103.
  • Tiwari A, Modi SJ, Girme A, Hingorani L. Network pharmacology-based strategic prediction and target identification of apocarotenoids and carotenoids from standardized Kashmir saffron(Crocus sativus L.) extract against polycystic ovary syndrome. Medicine2023;102:32(e34514). 
  • Tiwari, Anshuly, Siddharth J. Modi, Aboli Girme, and Lal Hingorani. “Network pharmacology-based strategic prediction and target identification of apocarotenoids and carotenoids from standardized Kashmir saffron (Crocus sativus L.) extract against polycystic ovary syndrome.” Medicine 102, no. 32 (2023): e34514.  DOI: 10.1097/MD.0000000000034514
  • Tripathi C, Girme A, Champaneri S, Patel RJ, Hingorani L. Nutraceutical regulations: An opportunity in ASEAN countries. Nutrition. 2020 Jun 1;74:110729.
  • Vandana J, Achal T, Lal H, Laddha KS. Lipid constituents from Cissus quadrangularis leaves. Pharmacognosy Research. 2009;1(4).

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